Highlighted Publications

Non-coding RNAs & Cancer (Luis Burzio)
Borgna, V., Lobos-González, L., Guevara, F., Landerer, E., Bendek, M., Ávila, R., Silva, V., Villota, C., Araya, M., Rivas, A., López, C., Socias, T., Castillo, J., Alarcón, L., Burzio, L. O., Burzio, V. A., & Villegas, J. (2020). Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors. Journal of Cancer, 11(7), 1780–1791. https://doi.org/10.7150/jca.38880
In vivo knockdown of ASncmtRNA induces apoptosis and tumor growth inhibition in xenograft and PDX murine models of bladder cancer.
Bioinformatics and Genome Biology (David Holmes)
Neira, G., Cortez, D., Jil, J., Holmes, D. S. AciDB 1.0: A database of acidophilic organisms, their genomic information and associated metadata. Bioinformatics (Oxford, England) DOI: 10.1093/bioinformatics/btaa638 (2020).
A searchable database has been constructed of over 500 high-quality genomes of acidophilic Bacteria and Archaea.
Immunoncology (Alvaro Lladser)
Menares E, Gálvez-Cancino F, Cáceres-Morgado P, Ghorani E, López E, Díaz X, Saavedra-Almarza J, Figueroa DA, Roa E, Quezada SA, Lladser A. Resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells. Nature Communications. 10(1):4401. doi: 10.1038/s41467-019-12319-x (2019).
This work demonstrated that tissue-resident memory CD8+ T cells amplify the breath of cytotoxic CD8+ T cell responses via DCs to strengthen anti-tumor immunity.
Epigenetics and Chromatin (Alejandra Loyola)
Saavedra F., Gurard-Levin ZA., Rojas-Villalobos C., Vassias I., Quatrini R., Almouzni G., Loyola A. JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability. Epigenetics & Chromatin. 13:6. DOI: 10.1186/s13072-020-00331-1 (2020)
This work supports a role for JMJD1B in fine-tuning histone supply to maintain genome integrity, opening
novel avenues for cancer therapeutics.
Biology of Neurodegeneration (Soledad Matus)
Falcón P, Escandón M, Brito Á, Matus S. Nutrient Sensing and Redox Balance: GCN2 as a New Integrator in Aging. Oxid Med Cell Longev. 2019 May 22;2019:5730532. doi: 10.1155/2019/5730532.
Growing evidence has revealed a contribution of stress responses in aging. Here, we review the possible interplay between amino acid sensing and redox balance maintenance mediated by the nutritional sensor general control nonderepressive 2 (GCN2).
Neuroimmunology (Rodrigo Pacheco)
Andro Montoya, Daniela Elgueta, Javier Campos, Ornella Chovar, Paulina Falcón, Soledad Matus, Iván Alfaro, María Rosa Bono, Rodrigo Pacheco. (2019). Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation. Journal of Neuroinflammation. 16(1): 258. doi. 10.1186/s12974-019-1652-8.
In this study we provide genetic and pharmacologic evidence showing how dopaminergic signalling in astrocytes promotes neuroinflammation in a mouse model.
Microbial Ecophysiology (Raquel Quatrini)
Moya-Beltrán A., Rojas-Villalobos C., Díaz M., Guiliani N., Quatrini R., Castro M. Nucleotide second messenger-based signaling in extreme acidophiles of the Acidithiobacillus species complex: partition between the core and variable gene complements. Front. Microbiol. 10: 381. DOI:10.3389/fmicb.2019.00381 (2019)
In this publication we address the challenge of disentangling the nucleotide-driven signal transduction pathways in the acidophilic bacterial genus Acidithiobacillus, using pangenome-based comparative genomic strategies. Molecular elements of c-di-GMP metabolism and transduction were mostly found scattered along the flexible genome of the acidithiobacilli, allowing the identification of probable control modules that could be critical for substrate colonization, biofilm development and intercellular interactions. Findings presented open new ways to explore molecular circuits to control biomining microorganism behaviours.
Cellular and Molecular Immunology (Mario Rosemblatt)
Y. Hidalgo, S. Núñez, M.J. Fuenzalida, F. Flores-Santibáñez, P.J. Sáez, J. Dorner, A.M. Lennon-Dumenil, V. Martínez, E. Zorn, M. Rosemblatt, D. Sauma and M.R. Bono. Thymic B cells promote germinal center-like structures and the expansion of follicular helper T cells in lupus-prone mice. Frontiers Immunology, Vol. 11, Article 696, April 2020. doi: 10.3389/fimmu.2020.00696
We found that in the thymus of Lupic mice there is an increased population of B cell that form ectopic germinal centers and produce anti-dsDNA autoantibodies. Thus, the thymus emerges as an important niche that supports the pathogenic humoral response in the development of murine Lupus.
Molecular Virology (Nicole Tischler)
Bignon EA, Albornoz A, Guardado-Calvo P, Rey FA, Tischler ND (2019). Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface. eLife 8. pii: e46028. doi: 10.7554/eLife.46028.
Functional characterization of molecular contacts between hantavirus spikes that control virus particle assembly and spike stability; identification of a temperature-dependent dynamic behavior of the spikes at neutral pH, alternating between ‘open’ and ‘closed’ forms.