Inmunology

PROFILE

Our laboratory works to understand the molecular mechanisms that regulate skeletal muscle formation and how they are affected in skeletal muscular dystrophies. Our laboratory has conducted extensive studies to understand the role of extracellular matrix (ECM) in skeletal muscle formation and regeneration and the comprehension of the fibrotic phenomena associated with skeletal muscular dystrophies.
We are interested in the understanding of the mechanisms involved in fibrosis associated with skeletal muscular diseases. Fibrosis corresponds to an increase in ECM constituents, which occurs in skeletal muscular dystrophies such as Duchenne Muscular Dystrophy (DMD), denervation, or loss of motor neuron activity (ALS). We study the role of profibrotic factors (TGF-, CTGF/CCN2), different components of the renin-angiotensin-system (RAS), and lysophosphatidic acid LPA in the genesis of skeletal muscle fibrosis. Also, we are interested in understanding the cell type(s) responsible for the fibrotic response in the different muscular models.

Correo electrónico: ebrandan@cienciavida.org

LAB MEMBERS

Research Head: Enrique Brandan

Doctoral Students: Adriana Córdova • Meilyn Cruz • Felipe Gallardo
Undergraduate Students: Alexia Bock
Research Assistants: Eduardo Ramirez • Darling Vera
Postdoctoral Fellows: Lina Correa

COLLABORATIONS

National Collaborations:
• Dra. María José Acuña (Universidad Bernardo O´Higgins)
• Dr. Claudio Cabello (Universidad Andrés Bello)
• Dra. Verónica Eisner (P. Universidad Católica de Chile)

International Collaboration:
• Dr. Roel Goldschmeding (Utrecht University, The Netherlands)
• Dr. Kenneth E. Lipson (FibroGen, USA)
• Dr. Fabio Rossi (University of British Columbia, Canada)

FORMER LAB MEMBERS

Ph.D. students:
María José Acuña, Ph.D. Curr. Pos. Assistant Professor, Universidad Bernardo O’Higgins, Santiago, Chile
Claudio Cabello-Verrugio, Ph.D. Curr. Pos. Full Professor, Universidad Andrés Bello, Santiago, Chile
Daniel Cabrera, Ph.D. Curr. Pos. Research Associate, P. Universidad Católica de Chile, Santiago, Chile
Juan Carlos Casar, MD/Ph.D. Curr. Pos. Assistant Professor, P. Universidad Católica de Chile, Santiago, Chile
Rebeca Droguett, Ph.D. Curr. Pos. Teacher in Science, Santiago, College, Santiago, Chile
Jaime Gutierrez, Ph.D. Curr. Pos. Associate Professor, Universidad San Sebastián, Santiago, Chile
Juan Pablo Henríquez, Ph.D. Curr. Pos. Full Professor, Universidad de Concepción, Concepción, Chile
Claudia Hurtado, Ph.D. Curr. Pos. Research Associate. Clínica Las Condes, Santiago, Chile
Juan Larraín, Ph.D. Curr. Pos. Full Professor, P. Universidad Católica de Chile, Santiago, Chile
Valeria Mezzano, M.D./Ph.D. Curr. Pos. Assistant Professor, NYU Langone Medical Center, USA
María Gabriela Morales, Ph.D. Curr. Pos. Research Associate, University of Texas Southwestern M.C. USA
Hugo Olguín, Ph.D. Curr. Pos. Associate Professor, P. Universidad Católica de Chile, Santiago, Chile
Nelson Osses, Ph.D. Curr. Pos. Full Professor, Universidad Católica de Valparaiso, Valparaíso, Chile
Cecilia Riquelme, Ph.D. Curr. Pos. Associate Professor, P. Universidad Católica de Chile, Santiago, Chile
Cecilia Vial, Ph.D. Curr. Pos. Associate Professor, Universidad del Desarrollo, Santiago, Chile.
Gonzalo Cordova, Ph.D. Curr. Pos. Scientific Editor Springer Nature B.V. Rotterdam, The Netherlands
Andrés Ramirez, Ph.D. Curr. Pos. Regional Specialist. United Arab Emirates
David Gonzalez, Curr. Pos. Postdoctoral Fellow. Institut des Neurosciences de Montpellier, France
Osvaldo Contreras, Ph.D. Victor Chang Cardiac Research Institute, Darlinghurst, Australia
Roger Valle-Tenney, Université Catholique de Louvain, Belgium.
Adriana Córdova, Ph.D.(c). P. Universidad Católica de Chile
Meilyn Cruz, Ph.D.(c). P. Universidad Católica de Chile
Felipe Gallardo, Graduate student, P. Universidad Católica de Chile

Postdoctoral Fellows:
Claudio Cabello-Verrugio, Ph.D. Curr. Pos. Full Professor, Universidad Andrés Bello, Santiago, Chile
Daniel Cabrera, Ph.D. Curr. Pos. Research Associate, P. Universidad Católica de Chile, Santiago, Chile
Cristián Droppelmann, Ph.D. Curr. Pos. Reasearch Associate, The University of Western Ontario, Canada
Verónica Eisner, Ph.D. Curr. Pos. Assistant Professor, P. Universidad Católica de Chile, Santiago, Chile
Jaime Gutiérrez, Ph.D. Curr. Pos. Associate Professor, Universidad San Sebastián, Santiago, Chile
Daniela Rebolledo, Ph.D. Independent Researcher, CEBIMA, Punta Arenas, Chile.
Cecilia Riquelme, Ph.D. Curr. Pos. Associate Professor, P. Universidad Católica de Chile, Santiago, Chile
Cecilia Vial, Ph.D. Curr. Pos. Associate Professor, Universidad del Desarrollo, Santiago, Chile.
Joan Villena, Ph.D. Curr. Pos. Assistant Professor, Universidad de Valparaíso, Valparaíso, Chile
Gonzalo Ugarte, Ph.D. Curr. Pos. Associate Professor, Universidad de Santiago, Santiago, Chile

SELECTED PUBLICATIONS

  • Krukowski K., Nolan A., Frias ES., Boone M., Ureta G., Grue K., Paladini MS., Elizarras E., Delgado L., Bernales S., Walter P, Rosi S. (2020) Small molecule cognitive enhancer reverses age-related memory decline in mice. Elife 2020;9:e62048. DOI: 10.7554/eLife.62048 | | ABSTRACT
  • Krukowski K., Nolan A., Frias ES., Grue K., Becker M., Ureta G., Delgado L., Bernales S., Sohal VS., Walter P. (2020) Integrated stress response inhibitor reverses sex-dependent behavioral and cell-specific deficits after mild repetitive head trauma. Journal of Neurotrauma.37(1). DOI: 10.1089/neu.2019.6827 | | ABSTRACT
  • Jadhavar PS, Ramachandran SA, Riquelme E, Gupta A, Quinn KP, Shivakumar D, Ray S, Zende D, Nayak AK, Miglani SK, Sathe BD, Raja M, Farias O, Alfaro I, Belmar S, Guerrero J, Bernales S, Chakravarty S, Hung DT, Lindquist JN, Rai R. Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5222-5228. doi: 10.1016/j.bmcl.2016.09.058. Epub 2016 Oct 4. PubMed PMID: 27717544. | | ABSTRACT
  • Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 2015 May 19;4. doi:10.7554/eLife.05434. PubMed PMID: 25986605; PubMed Central PMCID: PMC4436593. | | ABSTRACT
  • Cochrane DR, Bernales S, Jacobsen BM, Cittelly DM, Howe EN, D'Amato NC, Spoelstra NS, Edgerton SM, Jean A, Guerrero J, Gómez F, Medicherla S, Alfaro IE, McCullagh E, Jedlicka P, Torkko KC, Thor AD, Elias AD, Protter AA, Richer JK. Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide. Breast Cancer Res. 2014 Jan 22;16(1):R7. doi: 10.1186/bcr3599. PubMed PMID: 24451109; PubMed Central PMCID: PMC3978822. | PDF | ABSTRACT
  • Guerrero J, Alfaro IE, Gómez F, Protter AA, Bernales S. Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate. 2013 Sep;73(12):1291-305. doi:10.1002/pros.22674. Epub 2013 Jun 13. PubMed PMID: 23765603. | PDF | ABSTRACT
  • Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S. Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Mol Psychiatry. 2013 Aug;18(8):882-8. doi:10.1038/mp.2012.115. Epub 2012 Aug 7. PubMed PMID: 22869031; PubMed Central PMCID: PMC3523214. | PDF | ABSTRACT
  • Bernales S, Schuck S, Walter P. ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy. 2007 May-Jun;3(3):285-7. Epub 2007 May 1. PubMed PMID: 17351330. | PDF | ABSTRACT
  • Bernales S, McDonald KL, Walter P. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol. 2006 Nov;4(12):e423. PubMed PMID: 17132049; PubMed Central PMCID: PMC1661684. | PDF | ABSTRACT
  • Walther TC, Brickner JH, Aguilar PS, Bernales S, Pantoja C, Walter P. Eisosomes mark static sites of endocytosis. Nature. 2006 Feb 23;439(7079):998-1003. PubMed PMID: 16496001. | PDF | ABSTRACT
  • Bernales S, Papa FR, Walter P. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol. 2006;22:487-508. Review. PubMed PMID:16822172. | PDF | ABSTRACT